Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS??? EQUITY

CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Advisory Board And Consultants	Employees	Preferred Stock	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Advisory Board And Consultants	Additional Paid-In Capital Employees	Accumulated Deficit	Noncontrolling Interest
Beginning Balance (in shares) at Dec. 31, 2015				14,683,021	182,338,038
Beginning Balance at Dec. 31, 2015	$ 376,031			$ 1	$ 19	$ 511,138			$ (135,156)	$ 29
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)					210,330
Issuance of common stock under employee stock purchase plan	481					481
Exercise of stock options (in shares)					3,920,950
Exercise of stock options	2,580					2,580
Exercise of warrants (in shares)					12,389,544
Exercise of warrants	17,976					17,976
Stock-based compensation		$ 50	$ 5,261				$ 50	$ 5,261
Issuance of restricted stock (in shares)					1,331,000
Repurchase and retirement of common stock (in shares)					(6,132,124)
Repurchase and retirement of common stock	(14,749)					(14,749)
Third party investment in noncontrolling interest	40									40
Preferred stock issued, net of underwriting discount and expense (in shares)				1,161,895
Preferred stock issued, net of underwriting discount and expense	27,580					27,580
Preferred stock dividends declared and paid	(30,438)					(30,438)
Net loss	(22,311)								(22,269)	(42)
Ending Balance (in shares) at Dec. 31, 2016				15,844,916	194,057,738
Ending Balance at Dec. 31, 2016	362,501			$ 1	$ 19	519,879			(157,425)	27
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)					167,016
Issuance of common stock under employee stock purchase plan	420					420
Exercise of stock options (in shares)					2,661,647
Exercise of stock options	4,826				$ 1	4,825
Exercise of warrants (in shares)					2,000,000
Exercise of warrants	3,820					3,820
Stock-based compensation		57	5,482				57	5,482
Issuance of restricted stock (in shares)					1,791,000
Restricted stock forfeitures (in shares)					(5,000)
Repurchase and retirement of common stock (in shares)					(2,088,460)
Repurchase and retirement of common stock	(5,293)					(5,293)
Repurchase of option award for cash	(850)					(850)
Preferred stock issued, net of underwriting discount and expense (in shares)				1,167,159
Preferred stock issued, net of underwriting discount and expense	28,095			$ 1		28,094
Preferred stock dividends declared and paid	(32,482)					(32,482)
Commons stock dividends declared and paid	(3,880)					(3,880)
Net loss	7,682								7,697	(15)
Ending Balance (in shares) at Dec. 31, 2017				17,012,075	198,583,941
Ending Balance at Dec. 31, 2017	370,391			$ 2	$ 20	520,135			(149,778)	12
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Cumulative effect of adoption of ASU	24,785								24,774	11
Cumulative effect of adoption of ASU \| Accounting Standards Update 2016-09	13					63			(50)
Beginning balance, adjusted	395,176			$ 2	$ 20	520,135			(125,004)	23
Issuance of common stock under employee stock purchase plan (in shares)					161,968
Issuance of common stock under employee stock purchase plan	453					453
Exercise of stock options (in shares)					3,199,511
Exercise of stock options	3,813					3,813
Stock-based compensation		$ 34	$ 5,848				$ 34	$ 5,848
Issuance of restricted stock (in shares)					2,172,000
Restricted stock forfeitures (in shares)					106,250
Repurchase and retirement of common stock (in shares)					(57,475,374)
Repurchase and retirement of common stock	(139,835)				$ (6)	(139,829)
Repurchase of option award for cash	(3,000)					(3,000)
Preferred stock issued, net of underwriting discount and expense	(273)					(273)
Preferred stock dividends declared and paid	(34,031)					(34,031)
Commons stock dividends declared and paid	(8,794)					(8,794)
Net loss	33,786								33,758	28
Ending Balance (in shares) at Dec. 31, 2018				17,012,075	146,535,796
Ending Balance at Dec. 31, 2018	$ 253,177			$ 2	$ 14	$ 344,356			$ (91,246)	$ 51