Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS??? EQUITY

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CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS’ EQUITY - USD ($)
$ in Thousands
Total
Advisory Board And Consultants
Employees
Preferred Stock
Common Stock
Additional Paid-In Capital
Additional Paid-In Capital
Advisory Board And Consultants
Additional Paid-In Capital
Employees
Accumulated Deficit
Noncontrolling Interest
Beginning Balance (in shares) at Dec. 31, 2014       11,096,231 184,968,487          
Beginning Balance at Dec. 31, 2014 $ 336,471     $ 1 $ 18 $ 460,446     $ (124,005) $ 11
Increase (Decrease) in Stockholders' Equity [Roll Forward]                    
Issuance of common stock under employee stock purchase plan (in shares)         192,978          
Issuance of common stock under employee stock purchase plan 545         545        
Exercise of stock options (in shares)         1,194,425          
Exercise of stock options 1,471         1,471        
Exercise of warrants (in shares)         449,482          
Stock-based compensation   $ 3,183 $ 5,576       $ 3,183 $ 5,576    
Issuance of restricted stock (in shares)         1,206,081          
Issuance of restricted stock 1       $ 1          
Repurchase and retirement of common stock (in shares)         (5,673,415)          
Repurchase and retirement of common stock (16,355)         (16,355)        
Third party investment in noncontrolling interest 80                 80
Preferred stock issued, net of underwriting discount and expense (in shares)       3,586,790            
Preferred stock issued, net of underwriting discount and expense 84,380         84,380        
Preferred stock dividends declared and paid (28,108)         (28,108)        
Net loss (11,213)               (11,151) (62)
Ending Balance (in shares) at Dec. 31, 2015       14,683,021 182,338,038          
Ending Balance at Dec. 31, 2015 376,031     $ 1 $ 19 511,138     (135,156) 29
Increase (Decrease) in Stockholders' Equity [Roll Forward]                    
Issuance of common stock under employee stock purchase plan (in shares)         210,330          
Issuance of common stock under employee stock purchase plan 481         481        
Exercise of stock options (in shares)         3,920,950          
Exercise of stock options 2,580         2,580        
Exercise of warrants (in shares)         12,389,544          
Exercise of warrants 17,976         17,976        
Stock-based compensation   50 5,261       50 5,261    
Issuance of restricted stock (in shares)         1,331,000          
Repurchase and retirement of common stock (in shares)         (6,132,124)          
Repurchase and retirement of common stock (14,749)         (14,749)        
Third party investment in noncontrolling interest 40                 40
Preferred stock issued, net of underwriting discount and expense (in shares)       1,161,895            
Preferred stock issued, net of underwriting discount and expense 27,580         27,580        
Preferred stock dividends declared and paid (30,438)         (30,438)        
Net loss (22,311)               (22,269) (42)
Ending Balance (in shares) at Dec. 31, 2016       15,844,916 194,057,738          
Ending Balance at Dec. 31, 2016 362,501     $ 1 $ 19 519,879     (157,425) 27
Increase (Decrease) in Stockholders' Equity [Roll Forward]                    
Issuance of common stock under employee stock purchase plan (in shares)         167,016          
Issuance of common stock under employee stock purchase plan 420         420        
Exercise of stock options (in shares)         2,661,647          
Exercise of stock options 4,826       $ 1 4,825        
Exercise of warrants (in shares)         2,000,000          
Exercise of warrants 3,820         3,820        
Stock-based compensation   $ 57 $ 5,482       $ 57 $ 5,482    
Issuance of restricted stock (in shares)         1,791,000          
Restricted stock forfeitures (in shares)         (5,000)          
Repurchase and retirement of common stock (in shares)         (2,088,460)          
Repurchase and retirement of common stock (5,293)         (5,293)        
Repurchase of option award for cash (850)         (850)        
Preferred stock issued, net of underwriting discount and expense (in shares)       1,167,159            
Preferred stock issued, net of underwriting discount and expense 28,095     $ 1   28,094        
Preferred stock dividends declared and paid (32,482)         (32,482)        
Commons stock dividends declared and paid (3,880)         (3,880)        
Net loss 7,682               7,697 (15)
Ending Balance (in shares) at Dec. 31, 2017       17,012,075 198,583,941          
Ending Balance at Dec. 31, 2017 370,391     $ 2 $ 20 520,135     (149,778) $ 12
Increase (Decrease) in Stockholders' Equity [Roll Forward]                    
Cumulative effect of adoption of ASU 2016-09 (Note 1) | Accounting Standards Update 2016-09 $ 13         $ 63     $ (50)