Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS??? EQUITY

CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Advisory Board And Consultants	Employees	Preferred Stock	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Advisory Board And Consultants	Additional Paid-In Capital Employees	Accumulated Deficit	Noncontrolling Interest
Beginning Balance (in shares) at Dec. 31, 2014				11,096,231	184,968,487
Beginning Balance at Dec. 31, 2014	$ 336,471			$ 1	$ 18	$ 460,446			$ (124,005)	$ 11
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)					192,978
Issuance of common stock under employee stock purchase plan	545					545
Exercise of stock options (in shares)					1,194,425
Exercise of stock options	1,471					1,471
Exercise of warrants (in shares)					449,482
Stock-based compensation		$ 3,183	$ 5,576				$ 3,183	$ 5,576
Issuance of restricted stock (in shares)					1,206,081
Issuance of restricted stock	1				$ 1
Repurchase and retirement of common stock (in shares)					(5,673,415)
Repurchase and retirement of common stock	(16,355)					(16,355)
Third party investment in noncontrolling interest	80									80
Preferred stock issued, net of underwriting discount and expense (in shares)				3,586,790
Preferred stock issued, net of underwriting discount and expense	84,380					84,380
Preferred stock dividends declared and paid	(28,108)					(28,108)
Net loss	(11,213)								(11,151)	(62)
Ending Balance (in shares) at Dec. 31, 2015				14,683,021	182,338,038
Ending Balance at Dec. 31, 2015	376,031			$ 1	$ 19	511,138			(135,156)	29
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)					210,330
Issuance of common stock under employee stock purchase plan	481					481
Exercise of stock options (in shares)					3,920,950
Exercise of stock options	2,580					2,580
Exercise of warrants (in shares)					12,389,544
Exercise of warrants	17,976					17,976
Stock-based compensation		50	5,261				50	5,261
Issuance of restricted stock (in shares)					1,331,000
Repurchase and retirement of common stock (in shares)					(6,132,124)
Repurchase and retirement of common stock	(14,749)					(14,749)
Third party investment in noncontrolling interest	40									40
Preferred stock issued, net of underwriting discount and expense (in shares)				1,161,895
Preferred stock issued, net of underwriting discount and expense	27,580					27,580
Preferred stock dividends declared and paid	(30,438)					(30,438)
Net loss	(22,311)								(22,269)	(42)
Ending Balance (in shares) at Dec. 31, 2016				15,844,916	194,057,738
Ending Balance at Dec. 31, 2016	362,501			$ 1	$ 19	519,879			(157,425)	27
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)					167,016
Issuance of common stock under employee stock purchase plan	420					420
Exercise of stock options (in shares)					2,661,647
Exercise of stock options	4,826				$ 1	4,825
Exercise of warrants (in shares)					2,000,000
Exercise of warrants	3,820					3,820
Stock-based compensation		$ 57	$ 5,482				$ 57	$ 5,482
Issuance of restricted stock (in shares)					1,791,000
Restricted stock forfeitures (in shares)					(5,000)
Repurchase and retirement of common stock (in shares)					(2,088,460)
Repurchase and retirement of common stock	(5,293)					(5,293)
Repurchase of option award for cash	(850)					(850)
Preferred stock issued, net of underwriting discount and expense (in shares)				1,167,159
Preferred stock issued, net of underwriting discount and expense	28,095			$ 1		28,094
Preferred stock dividends declared and paid	(32,482)					(32,482)
Commons stock dividends declared and paid	(3,880)					(3,880)
Net loss	7,682								7,697	(15)
Ending Balance (in shares) at Dec. 31, 2017				17,012,075	198,583,941
Ending Balance at Dec. 31, 2017	370,391			$ 2	$ 20	520,135			(149,778)	$ 12
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Cumulative effect of adoption of ASU 2016-09 (Note 1) \| Accounting Standards Update 2016-09	$ 13					$ 63			$ (50)