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Exhibit 16.1

May 16, 2025

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Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

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Commissioners:

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We have read the statements made by CytoDyn Inc. under Item 4.01 of its Form 8-K dated May 16, 2025.  We agree with the statements concerning our Firm in such Form 8-K; we are not in a position to agree or disagree with other statements of CytoDyn Inc. contained therein.

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Very truly yours,

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/s/ Marcum llp

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Marcum llp