Annual report pursuant to Section 13 and 15(d)

Collaboration and License Agreements - Accounts Receivable from the Kowa Contract (Detail)

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Collaboration and License Agreements - Accounts Receivable from the Kowa Contract (Detail)
$ in Thousands
Dec. 31, 2017
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Accounts Receivable $ 5,000
Kowa Pharmaceuticals America Inc [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Accounts Receivable $ 5,000