FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Su Lisa T
   2. Issuer Name and Ticker or Trading Symbol
ADVANCED MICRO DEVICES INC [AMD] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President & CEO
(Last)
(First)
(Middle)
2485 AUGUSTINE DRIVE		 3. Date of Earliest Transaction (Month/Day/Year)
11/09/2021
(Street)

SANTA CLARA, CA 95054		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/09/2021   M   125,000 (1) A $ 2.92 2,283,150 (2) D  
Common Stock 11/09/2021   S   2,708 (3) D $ 144.95 (4) 2,280,442 D  
Common Stock 11/09/2021   S   4,420 (3) D $ 145.81 (5) 2,276,022 D  
Common Stock 11/09/2021   S   12,862 (3) D $ 147.03 (6) 2,263,160 D  
Common Stock 11/09/2021   S   28,946 (3) D $ 148.01 (7) 2,234,214 D  
Common Stock 11/09/2021   S   59,419 (3) D $ 148.81 (8) 2,174,795 D  
Common Stock 11/09/2021   S   3,800 (3) D $ 149.77 (9) 2,170,995 D  
Common Stock 11/09/2021   S   2,800 (3) D $ 150.86 (10) 2,168,195 D  
Common Stock 11/09/2021   S   4,502 (3) D $ 152.08 (11) 2,163,693 D  
Common Stock 11/09/2021   S   2,643 (3) D $ 152.9 (12) 2,161,050 D  
Common Stock 11/09/2021   S   1,900 (3) D $ 154.24 (13) 2,159,150 D  
Common Stock 11/09/2021   S   1,000 (3) D $ 155.08 (14) 2,158,150 D  
Common Stock               133,453 I By Grantor Retained Annuity Trust (15)
Common Stock               200,000 I By Grantor Retained Annuity Trust 2021A (16)
Common Stock               200,000 I By Grantor Retained Annuity Trust 2021B (16)
Common Stock               200,000 I By Grantor Retained Annuity Trust 2021C (16)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option Grant $ 2.92 11/09/2021   M     125,000   (17) 12/26/2022 Common Stock 125,000.00 $ 0 878,457 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Su Lisa T
2485 AUGUSTINE DRIVE
SANTA CLARA, CA 95054		   X     President & CEO  

Signatures

 /s/Linda Lam by Power of Attorney for Lisa T. Su   11/11/2021
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The stock option exercise reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 4, 2020.
(2) Includes: (i) an annuity distribution on November 5, 2021 of 66,547 shares of the Issuer's Common Stock from the Reporting Person's Grantor Retained Annuity Trust (GRAT), dated May 18, 2020, to the Reporting Person; and (ii) the contribution of 600,000 shares of the Issuer's Common Stock to the creation of three GRATs for the Reporting Person, as described in footnotes 15 and 16 below.
(3) The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 4, 2020.
(4) Transaction executed in multiple trades at prices ranging from $144.40 to $145.37 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(5) Transaction executed in multiple trades at prices ranging from $145.44 to $146.42 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(6) Transaction executed in multiple trades at prices ranging from $146.44 to $147.43 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(7) Transaction executed in multiple trades at prices ranging from $147.44 to $148.43 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(8) Transaction executed in multiple trades at prices ranging from $148.45 to $149.44 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(9) Transaction executed in multiple trades at prices ranging from $149.46 to $150.36 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(10) Transaction executed in multiple trades at prices ranging from $150.46 to $151.41 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(11) Transaction executed in multiple trades at prices ranging from $151.52 to $152.51 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(12) Transaction executed in multiple trades at prices ranging from $152.53 to $153.49 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(13) Transaction executed in multiple trades at prices ranging from $153.54 to $154.53 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(14) Transaction executed in multiple trades at prices ranging from $154.60 to $155.54 per share, inclusive. The price reported in column 4 above reflects the weighted average sale price per share. The Reporting Person hereby undertakes to provide the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
(15) On November 5, 2021, 66,547 shares were distributed to the Reporting Person as an annuity.
(16) On November 5, 2021, the Reporting Person contributed 200,000 shares of the Issuer's Common Stock to a GRAT for which the Reporting Person serves as a trustee and sole annuitant.
(17) This option vested 33 1/3% on December 26, 2016 and 8 1/3% per quarter over the subsequent eight quarters.

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